Alport syndrome: Overview, Causes

Alternate Names : Hereditary nephritis, Hematuria – nephropathy – deafness, Hemorrhagic familial nephritis, Hereditary deafness and nephropathy

Definition

Alport syndrome is an inherited disorder that damages tiny blood vessels in the kidneys.

Overview, Causes, & Risk Factors

Alport syndrome is an inherited form of kidney inflammation (nephritis). It is caused by a mutation in a gene for a protein in connective tissue, called collagen.

The disorder is uncommon, and most often affects males. Women can transmit the gene for the disorder to their children, even if they have no symptoms.

Risk factors include:

* End-stage kidney disease in male relatives
* Family history of Alport syndrome
* Glomerulonephritis
* Hearing loss before age 30
* Nephritis

Pictures & Images

Male urinary system

The urinary system is made up of the kidneys, ureters, urethra and bladder.

Alport syndrome: Overview, Causes

Alport syndrome: Symptoms & Signs, Diagnosis & Tests

Alport syndrome: Treatment


Review Date : 8/29/2008
Review Date : 11/30/2009
Reviewed By : David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Herbert Y. Lin, MD, PHD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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