Agammaglobulinemia: Symptoms & Signs, Diagnosis & Tests

Symptoms & Signs

Symptoms include frequent episodes of:

* Bronchitis
* Chronic diarrhea
* Conjunctivitis (eye infection)
* Otitis media (middle ear infection)
* Pneumonia
* Sinusitis
* Skin infections
* Upper respiratory tract infections

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Infections typically appear in the first 4 years of life.

Other symptoms include:

* Bronchiectasis (a disease in which the small air sacs in the lungs become damaged and enlarged)
* Unexplained asthma

Diagnosis & Tests

The disorder is confirmed by laboratory measurement of blood immunoglobulins.

Tests include:

* Flow cytometry to measure circulating B lymphocytes
* Immunoelectrophoresis – serum
* Quantitative immunoglobulins – IgG, IgA, IgM (usually measured by nephelometry)

Agammaglobulinemia: Overview, Causes

Agammaglobulinemia: Symptoms & Signs, Diagnosis & Tests

Agammaglobulinemia: Treatment


Review Date : 5/16/2010
Reviewed By : David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Stuart I. Henochowicz, MD, FACP, Associate CLinical Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, Georgetown University Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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