What is Muse (Alprostadil)?

What is the most important information I should know about Muse (Alprostadil)?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.
The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).
Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Your first dose of this medicine will be given in your doctor’s office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.
Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.
Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different from these averages.
Seek emergency medical attention if you think you have used too much of this medication. Symptoms of an alprostadil overdose may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I discuss with my healthcare provider before taking Muse (Alprostadil)?

Do not use alprostadil if you have:

sickle cell anemia or the sickle cell anemia trait
leukemia
a tumor of the bone marrow (multiple myeloma)
chronic urination problems
a history of blood clots
a curved or deformed penis
penile fibrosis or Peyronie’s disease; or
if you have been told you should not have sexual intercourse for health reasons

Before using alprostadil, tell your doctor if you have:

a bleeding or blood-clotting disorder
a disease that could be passed in blood (such as hepatitis or HIV)
heart disease
high blood pressure (hypertension); or
if you have a penile implant

If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.
Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.
Alprostadil should not be used by women or by anyone under 18 years old.

Muse Side Effects

What are the possible side effects of Muse (Alprostadil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using alprostadil and call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting
bleeding from your urethra
bleeding, bruising, or swelling where you injected the medication
a painful erection that lasts 4 hours or longer
severe pain or irritation of your penis or urethra; or
redness, lumps, tenderness, unusual shape or curving of the erect penis

Less serious side effects may include:

pain in your penis, urethra, or testicles
headache, dizziness
back pain
a rash on the skin of your penis
warmth or numbness of your penis; or
cough, stuffy nose, cold symptoms

Your sexual partner may also experience side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Muse Interactions

What other drugs affect Muse (Alprostadil)?

Before using alprostadil, tell your doctor if you are using any of the following drugs:

nitroglycerin
hydralazine (BiDil); or
a blood thinner such as warfarin (Coumadin), heparin, dalteparin (Fragmin), danaparoid (Orgaran), or enoxaparin (Lovenox)

This list is not complete and here may be other drugs that can interact with alprostadil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Muse (Alprostadil)?

Alprostadil can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Muse Dosage

How should I take Muse (Alprostadil)?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Using too much alprostadil can be very dangerous.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).
Your first dose of this medicine will be given in your doctor’s office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.
Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.
Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different from these averages.
To be sure this medication is not causing harmful effects, your penis will need to be examined on a regular basis. It is important that you not miss any scheduled appointments.
Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.
Do not mix alprostadil injectable or draw your dose into a syringe until you are ready to give yourself an injection. Do not shake the mixed medication. After mixing, the medication should be clear, without any particles in it.
Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.
An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.
Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.
Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days
Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first
Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel

What happens if I overdose on Muse (Alprostadil)?

Seek emergency medical attention if you think you have used too much of this medication. Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What happens if I miss a dose of Muse (Alprostadil)?

Since alprostadil is used as needed, you will not be on a dosing schedule.
Edited from everydayhealth.com

Muse (Alprostadil)