What is Frovatriptan?

Frovatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. Frovatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.
Frovatriptan is used to treat migraine headaches.
Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Frovatriptan should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches. Use this medication only if your condition has been confirmed by a doctor as migraine headaches.
Frovatriptan may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Frovatriptan?

You should not take this medication if you are allergic to frovatriptan, or if you have a history of heart disease, angina (chest pain), blood circulation problems, ischemic bowel disease, uncontrolled high blood pressure, or history of a heart attack or stroke.
Do not use frovatriptan within 24 hours before or after using another migraine headache medicine, including almotriptan (Axert), eletriptan (Relpax), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Treximet), zolmitriptan (Zomig), or ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), or methysergide (Sansert).
Before taking frovatriptan, tell your doctor if you have liver disease, high blood pressure, a heart rhythm disorder, coronary artery disease, or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
Before taking frovatriptan, tell your doctor if you are also taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor).
Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.

What should I discuss with my healthcare provider before taking Frovatriptan?

You should not use this medication if you are allergic to frovatriptan, or if you have:

a history of heart disease, angina (chest pain), blood circulation problems, heart attack, or stroke, including “mini-stroke”
ischemic bowel disease
severe or uncontrolled high blood pressure; or
a headache that is not like other headaches you have had

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before taking frovatriptan, tell your doctor if you have:

liver disease
heart disease, high blood pressure, a heart rhythm disorder; or
coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy)

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before taking frovatriptan, tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether frovatriptan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medicine to anyone under 18 years old.

Frovatriptan Side Effects

What are the possible side effects of Frovatriptan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using frovatriptan and call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
sudden numbness or weakness, especially on one side of the body
sudden headache, confusion, problems with vision, speech, or balance
sudden and severe stomach pain and bloody diarrhea
numbness or tingling and a pale or blue-colored appearance in your fingers or toes; or
(if you are also taking an antidepressant) – agitation, high fever, sweating, fast or pounding heartbeats, nausea, vomiting, diarrhea, loss of balance or coordination, overactive reflexes, hallucinations, fainting

Less serious side effects may include:

mild headache (not a migraine)
feeling too warm or too cold
dry mouth, upset stomach
bone or joint pain
feeling of pain or tightness in your jaw, neck, or throat
pressure or heavy feeling in any part of your body
dizziness, drowsiness, tired feeling; or
warmth, redness, or mild tingling under your skin

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Frovatriptan Interactions

What other drugs affect Frovatriptan?

Before taking frovatriptan, tell your doctor if you are using any of the following drugs:

propranolol (Inderal, InnoPran)
an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor)

This list is not complete and there may be other drugs that can interact with frovatriptan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Frovatriptan?

Do not take frovatriptan within 24 hours before or after using another migraine headache medicine, including:

almotriptan (Axert), eletriptan (Relpax), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex, Treximet), or zolmitriptan (Zomig); or
ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), or methysergide (Sansert)

Frovatriptan Dosage

How should I take Frovatriptan?

Take this medication exactly as it was prescribed for you. Never take the medication in larger amounts, or take it for longer than recommended by your doctor. Overuse of migraine headache medicine can actually make your headaches worse. Follow the instructions on your prescription label.
Take frovatriptan as soon as you notice headache symptoms, or after an attack has already begun.
Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.
Take one frovatriptan tablet whole with a full glass of water.
After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than three (3) frovatriptan tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.
Contact your doctor if you have more than four headaches in one month (30 days).
If you use frovatriptan long-term, your doctor may want to check your heart function periodically using an electrocardiograph or ECG (sometimes called an EKG), a machine that measures electrical activity of the heart. This will help your doctor determine if it is still safe for you to use this medication. Do not miss any scheduled visits to your doctor.
Store frovatriptan at room temperature away from moisture and heat.

What happens if I overdose on Frovatriptan?

Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of a frovatriptan overdose are not known.

What happens if I miss a dose of Frovatriptan?

Since frovatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using frovatriptan.
After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.
Sourced from everydayhealth.com

Frovatriptan