What is Fluoxetine Olanzapine?

Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).
Olanzapine is an antipsychotic medication. These drugs affect chemicals in the brain.
The combination of fluoxetine and olanzapine is used to treat depression caused by bipolar disorder (manic depression). Fluoxetine and olanzapine is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.
Fluoxetine and olanzapine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Fluoxetine Olanzapine?

This medication is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
Do not take fluoxetine and olanzapine together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), rasagiline (Azilect), phenelzine (Nardil), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine.
SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine and olanzapine, do not stop taking the medication without first talking to your doctor.

What should I discuss with my healthcare provider before taking Fluoxetine Olanzapine?

pimozide (Orap)
thioridazine (Mellaril); or
an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam)

Serious and sometimes fatal reactions can occur when these medicines are taken with fluoxetine and olanzapine. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine and olanzapine. You must wait 5 weeks after stopping fluoxetine and olanzapine before you can take thioridazine (Mellaril) or an MAO inhibitor.
If you have any of these other conditions, you may need a fluoxetine and olanzapine dose adjustment or special tests:

liver disease
heart disease, high or low blood pressure, or a history of heart attack or stroke
diabetes
high cholesterol or triglycerides
seizures or epilepsy
narrow-angle glaucoma
paralytic ileus (a stomach disorder)
breast cancer
enlarged prostate; or
a history of drug abuse or suicidal thoughts

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
FDA pregnancy category C. An SSRI antidepressant may cause serious lung problems in a newborn if you take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you become pregnant while taking fluoxetine and olanzapine, do not stop taking the medication without first talking to your doctor.
Fluoxetine and olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medication.
Do not give fluoxetine and olanzapine to anyone younger than 18 years old without the advice of a doctor.

Fluoxetine Olanzapine Side Effects

What are the possible side effects of Fluoxetine Olanzapine?

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have a serious side effect such as:

sudden and severe headache, chest pain, numbness, and problems with vision, speech, or balance
increased thirst, frequent urination, excessive hunger, or weakness
agitation, hallucinations, fever, fast heart rate, overactive reflexes, vomiting, diarrhea, loss of coordination
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
jerky muscle movements you cannot control
seizure (convulsions)
feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin
flu symptoms, easy bruising, sores in your mouth and throat; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Less serious side effects may include:

trouble swallowing, runny nose, sore throat
weight gain, swelling in your hands of feet
drowsiness, trouble concentrating, sleep problems (insomnia)
dry mouth, mild diarrhea, increased appetite
breast swelling or discharge (in women or men)
missed menstrual periods; or
decreased sex drive, impotence, or difficulty having an orgasm

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fluoxetine Olanzapine Interactions

What other drugs affect Fluoxetine Olanzapine?

Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine and olanzapine may cause you to bruise or bleed easily.
Before using fluoxetine and olanzapine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by fluoxetine and olanzapine.
Tell your doctor about all other medicines you use, especially:

vinblastine (Velban)
heart rhythm or blood pressure medication
tryptophan (sometimes called L-tryptophan)
lithium, clozapine (Clozaril, Fazaclo), haloperidol (Haldol)
phenytoin (Dilantin), carbamazepine (Carbatrol, Tegretol)
a blood thinner such as warfarin (Coumadin)
another form of fluoxetine or olanzapine such as Prozac, Prozac Weekly, Sarafem, or Zyprexa
theophylline (Theo-Dur, TheoBid, Uniphyl, Slo-Bid, Elixophyllin, and others)
medicine to treat Parkinson’s disease, such as bromocriptine (Parlodel), pergolide (Permax), pramipexole (Mirapex), ropinorole (Requip), or cabergoline (Cabaser)
almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or
any other antidepressants

This list is not complete and other drugs may interact with fluoxetine and olanzapine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What should I avoid while taking Fluoxetine Olanzapine?

Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking fluoxetine and olanzapine.
Drinking alcohol can increase certain side effects of fluoxetine and olanzapine.
Fluoxetine and olanzapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Fluoxetine Olanzapine Dosage

How should I take Fluoxetine Olanzapine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Fluoxetine and olanzapine can be taken with or without food. Try to take the medicine at the same time each day.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine.
Store at room temperature away from moisture and heat.

What happens if I overdose on Fluoxetine Olanzapine?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, tremor, problems with speech or vision, seizure (convulsions), and coma.

What happens if I miss a dose of Fluoxetine Olanzapine?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Sourced from everydayhealth.com

Fluoxetine Olanzapine