Endometriosis : Treatment

Treatment

Treatment options include:

• Medications to control pain
• Medications to stop the endometriosis from getting worse
• Surgery to remove the areas of endometriosis
• Hysterectomy with removal of both ovaries

Treatment depends on the following factors:

• Age
• Severity of symptoms
• Severity of disease
• Whether you want children in the future

Some women who do not ever want children and have mild disease and symptoms may choose to just have regular exams every 6 – 12 months so the doctor can make sure the disease isn’t getting worse. They may manage the symptoms by using:

• Exercise and relaxation techniques
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and naproxen (Aleve), acetaminophen (Tylenol), or prescription painkillers to relieve cramping and pain.

Treatment may involve stopping the menstrual cycle and creating a state resembling pregnancy. This is called pseudopregnancy. It can help prevent the disease from getting worse. It’s done using birth control pills containing estrogen and progesterone.

• You take the medicine continuously for 6 – 9 months before stopping the medicine for a week to have a period. Side effects include spotting of blood, breast tenderness, nausea, and other hormonal side effects.
• This type of therapy relieves most endometriosis symptoms, but it does not prevent scarring from the disease. It also does not reverse any physical changes that have already occurred.

Another treatment involves progesterone pills or injections. Side effects may be bothersome and include depression, weight gain, and spotting of blood.

Some women may be prescribed medicines that stop the ovaries from producing estrogen. These medicines are called gonadotropin agonist drugs and include nafarelin acetate (Synarel) and Depo Lupron.

• Potential side effects include menopausal symptoms such as hot flashes, vaginal dryness, mood changes, and early loss of calcium from the bones.
• Because of the bone density loss, this type of treatment is usually limited to 6 months. In some cases, it may be extended up to 1 year if small doses of estrogen and progesterone are given to reduce the bone weakening side effects.

Surgery is an option for women who have severe pain that does not improve with hormone treatment, or who want to become pregnant either now or in the future.

• Pelvic laparoscopy or laparotomy is done to diagnose endometriosis and then remove or destroy all of endometriosis-related tissue and scar tissue (adhesions).
• Women with severe symptoms or disease who do not want children in the future may have surgery to remove the uterus (hysterectomy). One or both ovaries and fallopian tubes may also be removed. One out of three women who do not have both of their ovaries removed at the time of hysterectomy will have their symptoms return and will need to have surgery at a later time to remove the ovaries.

Prognosis (Expectations)

Hormone therapy and pelvic laparoscopy cannot cure endometriosis. However, it can partially or completely relieve symptoms in many patients for a number of years.

Removing the uterus (hysterectomy), both ovaries and tubes give the best chance of a cure for endometriosis. You may need hormone replacement therapy after your ovaries are removed. Rarely endometriosis can come back, even after a hysterectomy.

Endometriosis may result in infertility, but not in every patient, and especially if the endometriosis is mild. Laparoscopic surgery may help improve fertility. The chance of success depends on the severity of the endometriosis. If the first surgery does not aid in getting pregnant, repeating the laparoscopy is unlikely to help. Patients should consider further infertility treatments.

Complications

Endometriosis can lead to problems getting pregnant (infertility). Other complications include:

• Chronic or long-term pelvic pain that interferes with social and work activities
• Large cysts in the pelvis (called endometriomas) that may break open (rupture)

Other complications are rare. In a few cases, endometriosis implants may cause blockages of the gastrointestinal or urinary tracts.

Very rarely, cancer may develop in the areas of endometriosis after menopause.

Calling Your Health Care Provider

Call for an appointment with your health care provider if:

• You have symptoms of endometriosis
• Back pain or other symptoms come back after endometriosis is treated

Consider getting screened for endometriosis if your mother or sister has been diagnosed with endometriosis, or if you are unable to become pregnant after trying for 1 year.

• Endometriosis : Overview, Causes, & Risk Factors

• Endometriosis : Symptoms & Signs, Diagnosis & Tests

• Endometriosis : Treatment

Review Date : 9/2/2009
Reviewed By : Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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