Chronic granulomatous disease : Symptoms & Signs, Diagnosis & Tests

Symptoms & Signs

  • Bone infections
  • Frequent and difficult-to-clear skin infections
    • Abscesses
    • Chronic infection inside the nose
    • Furuncles
    • Impetiginized eczema (eczema complicated by an infection)
    • Impetigo
    • Perianal abscesses (abscesses around the anus)
  • Joint infections
  • Persistent diarrhea
  • Pneumonia
    • Occurs frequently
    • Difficult to cure
  • Swollen lymph nodes in the neck; those develop early in life, and stay swollen or occur frequently. The lymph nodes may form abscesses that require surgical drainage.

Diagnosis & Tests

Physical examination may show an enlarged liver (hepatomegaly), enlarged spleen (splenomegaly), and swelling of multiple lymph nodes all over the body (generalized adenopathy). There may be signs of osteomyelitis, sometimes affecting multiple bones.

A tissue biopsy may show granulomas (groups of abnormal phagocytes).

Other tests may include:

  • Bone scan
  • Chemiluminescence assay to confirm the disease
  • Chest X-ray
  • Complete Blood Count
  • ESR
  • Liver scan
  • Nitroblue tetrazolium test (NBT) to confirm the disease and detect that the mother is a carrier


Review Date : 9/28/2008
Reviewed By : David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

adam.com

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

Tags: , , , .

Leave a comment