Alternate Names : Lou Gehrig’s disease, ALS, Upper and lower motor neuron disease, Motor neuron disease
Definition
Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement.
ALS is also known as Lou Gehrig’s disease.
Overview, Causes, & Risk Factors
In about 10% of cases, ALS is caused by a genetic defect. In other cases, the cause is unknown.
In ALS, nerve cells (neurons) waste away or die, and can no longer send messages to muscles. This eventually leads to muscle weakening, twitching, and an inability to move the arms, legs, and body. The condition slowly gets worse. When the muscles in the chest area stop working, it becomes hard or impossible to breathe on one’s own.
ALS affects approximately 1 out of every 100,000 people.
Except for having a family member who has a hereditary form of the disease, there are no known risk factors.
Pictures & Images
Central nervous system and peripheral nervous system
The central nervous system is comprised of the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.
Amyotrophic lateral sclerosis: Overview, Causes
Amyotrophic lateral sclerosis: Symptoms & Signs, Diagnosis & Tests
Amyotrophic lateral sclerosis: Treatment
Reviewed By : Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
