What is Evamist?

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
Estradiol topical is used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.
Estradiol topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Evamist?

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a bleeding disorder, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding.
This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Estrogens will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estrogens may also increase your risk of uterine or ovarian cancer.
Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol topical.

What should I discuss with my healthcare provider before taking Evamist?

Estrogens will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estrogens may also increase your risk of uterine or ovarian cancer.
Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
You should not use estradiol topical if you have:

a bleeding or blood-clotting disorder
liver or kidney disease
a history of stroke or circulation problems
abnormal vaginal bleeding that a doctor has not checked; or
any type of breast, uterine, or hormone-dependent cancer

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Tell your doctor if you have:

high blood pressure, angina, or heart disease
high cholesterol or triglycerides
kidney disease
asthma
epilepsy or other seizure disorder
migraines
diabetes
depression
gallbladder disease; or
if you have had your uterus removed (hysterectomy)

FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol topical if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.
Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol topical.

Evamist Side Effects

What are the possible side effects of Evamist?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
sudden numbness or weakness, headache, confusion, or problems with vision, speech, or balance
pain or swelling in your lower leg
abnormal vaginal bleeding
pain, swelling, or tenderness in your stomach
jaundice (yellowing of the skin or eyes); or
a lump in your breast

Less serious side effects may include:

nausea, vomiting, loss of appetite
swollen breasts
acne or skin color changes
vaginal pain, dryness, or discomfort, decreased sex drive, impotence, or difficulty having an orgasm
swelling, weight gain
migraine headaches, dizziness, depression; or
break-through bleeding, vaginal itching or discharge

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Evamist Interactions

What other drugs affect Evamist?

Tell your doctor about all other medications you use, especially:

St. John’s wort
a blood thinner such as warfarin (Coumadin)
ritonavir (Norvir)
carbamazepine (Carbatrol, Tegretol) or phenobarbital (Luminal, Solfoton)
an antibiotic such as clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), or rifampin (Rifadin, Rifater, Rifamate, Rimactane)
an antifungal medication such as ketoconazole (Nizoral) or itraconazole (Sporanox)

This list is not complete and there may be other drugs that can interact with estradiol topical. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Evamist?

Do not apply sunscreen to your skin at the same time you apply estradiol topical.
Avoid getting this medication in your eyes, and rinse thoroughly with water if this does happen.
Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Evamist Dosage

How should I take Evamist?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.
This medication comes with patient instructions for safe and effective use, and directions for priming the spray or gel pump if needed. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Apply estradiol topical only to clean, dry, unbroken skin. Do not apply to skin that is red or irritated. Never apply this medicine to the breasts.
To use the topical gel (such as Estrogel):

Apply estradiol topical gel to the outside of your arm, from wrist to shoulder. Use the gel at the same time each day
Do not rub the gel in, but allow it to dry on your skin for at least 5 minutes before you dress
This medication is flammable. Avoid smoking or being near an open flame until the medicine has dried completely

To use the topical emulsion (such as Estrasorb):

Apply this medicine while you are sitting down. You will use two foil pouches each time you apply this medication, unless your doctor has told you otherwise
Cut or tear open the foil pouch and place the pouch on top of your left thigh, with the open end of the pouch pointing toward your knee
Hold the pouch with one hand and use the fingers of your other hand to gently push all of the medicine out of the pouch and onto your thigh
Spend at least 3 minutes rubbing the gel into your entire left thigh and calf. Rub any excess medicine onto your buttocks
Cut or tear open the second pouch and apply the medicine to your right leg using the same method described above

To use the topical spray (such as Evamist):

Apply the spray to the skin on the inside of your forearm, just below the elbow. Use the spray at the same time each day
Place the cone of the spray applicator directly to your skin and hold the pump upright. Press the pump fully one spray. If your doctor has prescribed more than one spray, choose a different place on your inside forearm for the second spray. Use only the number of sprays your doctor has recommended
Do not rub the spray in, but allow it to dry on your skin for at least 2 minutes before you dress. Do not wash your arm for at least 30 minutes after applying the spray

Wash your hands with soap and water after applying the gel or emulsion.
Avoid allowing other people to get this medicine on their skin. If this happens, wash the area thoroughly with soap and water.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol topical.
Store this medication at room temperature away from moisture and heat.

What happens if I overdose on Evamist?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, breast tenderness, drowsiness, and vaginal bleeding.

What happens if I miss a dose of Evamist?

Use the medication as soon as you remember. If your next dose is less than 12 hours away, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Sourced from everydayhealth.com

Evamist