What is Exenatide?

Exenatide is an injectable diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin more efficiently.
Exenatide is used to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with exenatide if needed.
Exenatide may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Exenatide?

Do not use exenatide to treat type 1 (insulin-dependent) diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use exenatide if you have severe kidney disease.
Before using exenatide, tell your doctor if you use any of these oral diabetes medications: acetohexamide (Dymelor), chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta), tolazamide (Tolinase), tolbutamide (Orinase).
You must use this medication within 60 minutes (1 hour) before eating a meal. If you miss a dose, use the medication as soon as you remember, but only if you have not yet eaten a meal. If you have already eaten a meal, wait until your next scheduled dose (1 hour before a meal) to use the medicine. Your exenatide doses should be spaced at least 6 hours apart. Do not use exenatide after eating a meal.
Stop using exenatide and call your doctor at once if you have severe pain in your upper stomach spreading to your back, with nausea, vomiting, and a fast heart rate. These could be symptoms of pancreatitis.
Use exenatide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor’s office. Visit your doctor regularly.
If you are using any type of antibiotic or birth control pill, take these medicines at least 1 hour before you use exenatide.

What should I discuss with my healthcare provider before taking Exenatide?

kidney disease (or if you are on dialysis)
problems with digestion; or
severe stomach disorders (gastroparesis)

FDA pregnancy category C. It is not known whether exenatide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether exenatide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Exenatide Side Effects

What are the possible side effects of Exenatide?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using exenatide and call your doctor at once if you have a serious side effect such as:

urinating less than usual or not at all
drowsiness, confusion, mood changes, increased thirst, diarrhea
swelling, weight gain, feeling short of breath
dull pain in your middle or lower back; or
severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate

Less serious side effects may include:

nausea, vomiting, heartburn
loss of appetite
weight loss; or
dizziness, headache, or feeling jittery

Know the signs of low blood sugar (hypoglycemia) and how to recognize them:

hunger, headache, confusion, irritability
drowsiness, weakness, dizziness, tremors
sweating, fast heartbeat
seizure (convulsions); or
fainting, coma (severe hypoglycemia can be fatal)

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Exenatide Interactions

What other drugs affect Exenatide?

Before using exenatide, tell your doctor if you use any oral (taken by mouth) diabetes medications. You may need a dose adjustment:

acetohexamide (Dymelor)
chlorpropamide (Diabinese)
glimepiride (Amaryl)
glipizide (Glucotrol)
glyburide (DiaBeta)
tolazamide (Tolinase); or
tolbutamide (Orinase)

Your doctor will tell you if any of your medication doses need to be changed.
This list is not complete and other drugs may interact with exenatide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What should I avoid while taking Exenatide?

Avoid drinking alcohol. It can lower your blood sugar.
If you are using any type of antibiotic or birth control pill, take these medicines at least 1 hour before you use exenatide.

Exenatide Dosage

How should I take Exenatide?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results. Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency. Do not change your dose of exenatide without first talking to your doctor. Use only the diabetes medications prescribed for you.
Exenatide is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
Exenatide is usually injected twice a day, before the morning and evening meal. You must use this medication within 60 minutes (1 hour) before eating the meal. Your exenatide doses should be given at least 6 hours apart. Do not use exenatide after eating a meal.
Use exenatide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Exenatide comes in a prefilled pen with a “Pen User Manual” showing instructions for using the pen and injecting the medicine. You must do a “New Pen Set-Up” one time only, when starting a new prefilled exenatide Pen. If you do this “New Pen Set-Up” before each injection, you will run out of medicine before 30 days.
Pen needles are not included with this medicine. Ask your doctor, diabetes counselor, or pharmacist which needle size is best for you.
Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor’s office. Visit your doctor regularly.
Store unused exenatide injection pens in the refrigerator, protected from light. Do not freeze them, and throw away any exenatide pen that has become frozen. After your first use of a pen, it may then be stored at room temperature, away from heat and bright light.
Use the exenatide pen for only 30 days and then throw it away, even if it still has medicine in it. Do not use the medicine after the expiration date on the label has passed. Do not store the exenatide pen with the needle attached.
If the needle is left on, medicine may leak from the pen or air bubbles may form in the cartridge. Keep your exenatide pen, pen needles, and all medicines out of the reach of children.

What happens if I overdose on Exenatide?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause severe nausea and vomiting, or signs of low blood sugar (headache, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and tremor).

What happens if I miss a dose of Exenatide?

Use the missed dose as soon as you remember, but only if you have not yet eaten a meal. Skip the missed dose if you have already eaten a meal, or if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Use la dosis pasada tan pronto se acuerde. Sáltese la dosis pasada si ya casi es hora para la siguiente dosis. No use más medicina para alcanzar la dosis pasada.
Sourced from everydayhealth.com

Exenatide