What is Piroxicam?

Piroxicam is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Piroxicam works by reducing hormones that cause inflammation and pain in the body.
Piroxicam is used to treat pain or inflammation caused by arthritis.
Piroxicam may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Piroxicam?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use piroxicam. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking piroxicam. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to piroxicam (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking piroxicam. Alcohol can increase the risk of stomach bleeding caused by piroxicam.
Avoid exposure to sunlight or artificial UV rays. Piroxicam can make your skin more sensitive to sunlight and sunburn may result.

What should I discuss with my healthcare provider before taking Piroxicam?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Do not use this medication if you are allergic to piroxicam, or if you have a history of allergic reaction to aspirin or other NSAIDs.
Before taking piroxicam, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot
• heart disease, congestive heart failure, high blood pressure
• a history of stomach ulcers or bleeding
• liver or kidney disease
• asthma
• polyps in your nose
• a bleeding or blood clotting disorder; or
• if you smoke

If you have any of these conditions, you may need a dose adjustment or special tests to safely take piroxicam.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking piroxicam during the last 3 months of pregnancy may harm the unborn baby. Do not take piroxicam during pregnancy unless your doctor has told you to.
Piroxicam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medicine to a child without the advice of a doctor.

Piroxicam Side Effects

What are the possible side effects of Piroxicam?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking piroxicam and seek medical attention or call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance
• black, bloody, or tarry stools
• coughing up blood or vomit that looks like coffee grounds
• swelling or rapid weight gain
• urinating less than usual or not at all
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash
• bruising, severe tingling, numbness, pain, muscle weakness; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions)

Less serious side effects may include:

• upset stomach, mild heartburn or stomach pain, diarrhea, constipation
• bloating, gas
• dizziness, headache, nervousness
• skin itching or rash
• blurred vision; or
• ringing in your ears

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Piroxicam Interactions

What other drugs affect Piroxicam?

Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with piroxicam may cause you to bruise or bleed easily.
Before taking piroxicam, tell your doctor if you are taking any of the following drugs:

• a blood thinner such as warfarin (Coumadin)
• lithium (Eskalith, Lithobid)
• methotrexate (Rheumatrex, Trexall)
• diuretics (water pills) such as furosemide (Lasix)
• steroids (prednisone and others)
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), and others; or
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others

This list is not complete and there may be other drugs that can interact with piroxicam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Piroxicam?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to piroxicam (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking piroxicam. Alcohol can increase the risk of stomach bleeding caused by piroxicam.
Avoid prolonged exposure to sunlight. Piroxicam may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Piroxicam Dosage

How should I take Piroxicam?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
If you switch brands of piroxicam, your dose needs may change. Follow your doctor’s instructions about how much medicine to take.
If you take piroxicam for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.
It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve.
Store piroxicam at room temperature away from moisture and heat.

What happens if I overdose on Piroxicam?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What happens if I miss a dose of Piroxicam?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Sourced from everydayhealth.com